Successful abortive treatment with cyclosporine in a pediatric patient with Stevens-Johnson syndrome

Authors

  • Timothy Dinh University of Michigan
  • Helen Bode University of North Carolina School of Medicine, Department of Dermatology
  • Elizabeth Nieman University of North Carolina School of Medicine, Department of Dermatology
  • Eric Zwemer University of North Carolina School of Medicine, Department of Pediatrics
  • Carolyn Ziemer University of North Carolina School of Medicine, Department of Dermatology

DOI:

https://doi.org/10.47265/cjim.v3i1.4140

Keywords:

Stevens-Johnson Syndrome, SJS-TEN, cyclosporine

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening dermatologic drug reactions with no standardized therapies. Recent evidence suggests cyclosporine may reduce mortality in SJS/TEN patients, but only a few case reports have demonstrated its use in pediatric populations. Our report describes a case of early pediatric SJS successfully treated with cyclosporine. We propose that cyclosporine be considered as an abortive therapy in early pediatric SJS and may halt significant disease progression.

References

Ng QX, Deyn MLZQ De, Venkatanarayanan N, et al. A meta-analysis of cyclosporine treatment for Stevens–Johnson syndrome/toxic epidermal necrolysis. J Inflamm Res 2018;11:135–142.

González-Herrada C, Rodríguez-Martín S, Cachafeiro L, et al. Cyclosporine Use in Epidermal Necrolysis Is Associated with an Important Mortality Reduction: Evidence from Three Different Approaches. J Invest Dermatol 2017;137:2092–2100.

Bastuji-Garin S, Fouchard N, Bertocchi M, et al. Scorten: A severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol 2000;115:149–153.

John J St., Ratushny V, Liu KJ, et al. Successful Use of Cyclosporin A for Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis in Three Children. Pediatr Dermatol 2017;34:540–546.

Alajmi A, Jfri A, Gomolin A, et al. A pediatric case of Stevens-Johnson syndrome/toxic epidermal necrolysis with rapid response to intravenous cyclosporine. JAAD Case Reports 2020;6:555–557.

Hsu DY, Brieva J, Silverberg NB, et al. Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States. J Am Acad Dermatol 2017;76:811-817.e4.

Koh MJA, and Tay YK. An update on Stevens-Johnson syndrome and toxic epidermal necrolysis in children. Curr Opin Pediatr 2009;21:505–510.

Additional Files

Published

2023-09-22

How to Cite

Dinh, T., Bode, H., Nieman, E., Zwemer, E., & Ziemer, C. (2023). Successful abortive treatment with cyclosporine in a pediatric patient with Stevens-Johnson syndrome. Carolina Journal of Interdisciplinary Medicine, 3(1), 56–59. https://doi.org/10.47265/cjim.v3i1.4140

Issue

Vol. 3 No. 1 (2023): Carolina Journal of Interdisciplinary Medicine

Section

Clinical Encounters

Categories

License

Copyright (c) 2023 Timothy Dinh, Helen Bode, Elizabeth Nieman, Eric Zwemer, Carolyn Ziemer

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.